ICNMM Slides

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Summary Surface roughness is believed to impact the SERS effect. Rougher surfaces tend to produce more SERS activity. We can manipulate the npMgF2 surface by changing the deposition temperature, in the form of changing the grain nucleation, shifting the overall grain size and roughness. I performed TEM tomography and segmentation to pull out distributions of…

Hello NRG! Thanks to Jim McGrath and NSF, St. John Fisher College students and myself will have the opportunity to conduct research at URNano and the McGrath Lab this summer.  I am an Assistant Professor at Fisher in the Biology Department, and my  background is in cellular immunology, with a focus on sterile inflammation.  Why…

Last week, I did another two wafers with different top oxide thicknesses to verify my hypothesis about the top oxide thickness effect on pores. The wafers were 20/15/03(bottom/middle/top) and 20/15/40. According to the hypothesis, the porosity of 20/15/03 would continue decreasing, where for the 20/15/40 structure, the porosity might drop. Same tip I used before,…

Vaccinex has developed an antibody, VX15/2503, for Semaphorin 4D, a molecule implicated in axonal guidance mediation and blood brain barrier (BBB) disruption.   The role of SiMPore in its partnership with Vaccinex is to produce a workable model of the BBB, with the ability to introduce flow conditions and measure an electric gradient across the membrane. …

In previous experiments where the affinity based capture of EVs in ALine devices was tested, issues were encountered. It was noticed that when capturing EVs on the ALine, the non-biotinylated slit membranes had captured a higher quantity of EVs compared to biotinylated membranes. This conclusion led us to question if the flow through the ALine…