Quality System and LOI Updates (August ’25)

We’ve long speculated that adding fluid flow over our tissue models would reduce the concentration of pro-inflammatory factors secreted in response to inflammatory challenges, dampening the overall inflammatory state compared to static culture. We now have evidence that this is true and the results are important as benchmarks for our future studies. In response to…

Introduction Over the past few months, I have been characterizing and comparing iPSC-derived monocytes (iMonocytes) with peripheral blood-derived (PB) monocytes. As I wrap up these experiments, we’ve decided to look at marker expression on iMonocytes and PB monocytes once they have been polarized to macrophages by culturing the iMonocytes or PB monocytes with HTEN051 fibroblasts…

The μSiM Vasc-SkM Microphysiological development can be separated into 4 parts: Media tuning for integrated culture Force sensing element setup Assembly of the μSiM Vasc-SkM and setting up the perfusion Transendothelial Electrical Resistance (TEER) measurement of the Vast component Work has been done on the first 2 parts. Media tuning for integrated culture In order…

CRE_Bispecific_Antibody_CRS_and_ICANS_Neurotoxicity_Guidance_Feb2024 51899285fnl_Immunotoxic Potential of PharmaceuticalsWe are considering Bispecific T cell engagers (BiTEs) [1] as an alternative to a CAR T driven cytokine release as an immunotherapy focused DDT. BiTEs are monoclonal antibodies engineered to have one arm that recognizes a T Cell surface antigen and another that recognizes a tumor antigen. There are number of…