From SiMPore’s Basecamp thread … 
These are the nanopore characteristics. So between 14% and 20% porosity across the wafer and between 43 nm and 50 nm average pore size.
So a little under-sized. I hope T-Cells and Monocytes can get through!
0.625% microporosity
0.625% microporosity
Program C. Gu – Harvard Seminal Experiments Reese and Karnolvsky 1967 Brightman and Reese (1969) Two unique features of CNS endothelium: Specialized tight junctions – Very low rate transcytosis. Tight Junction by EM Ben-Zvi et al 2014 Nature. Transcytosis becomes upregulated not tight junctions. 2-3x injection HRP injection. Tracer containing vessels travel in endothelial cells…
I posted previously about an issue we have with needing to strip the native oxide from the sacrificial silicon layer prior to performing the through-pore etch with XeF2 that enables separation of the oxide membrane from the wafer substrate. The issue is that the membrane is generally attacked by whatever etch method is used to…
In support of the bone infection studies done in the Schwarz lab at URMC, I have recently been tasked with coordinating a new collaboration with Dr. Yates lab in the Chemical Engineering department. The goal of this collaboration is to establish a method to coat our membranes with hydroxyapatite crystals. Two different methods were attempted,…
Recently, several studies on Staphylococcus aureus (S. aureus) have been hindered due to poor performance from assays using the µSiM-Canalicular Array (CA). As discussed here, we attempted to improve assay performance by coating our membranes with fibronectin. This did not work well and instead left us in a state of confusion as we did not…
This morning I did a little work with the track etched membranes (0.05um 13mm). I talked with Paul over in Hopeman and he is currently working on making a small coring tool to cut out the membranes (it should be done by the end of the day). In the mean time I figured out that…
Last week, we reported that it was possible to anneal membranes after they had been etched. Below is a summary of results from membranes that were annealed over a range of temps and under different conditions. w600 (20 nm oxide) w510X (40 nm oxide) amorph. anneal 700 C no defects no defects amorph. anneal 750…
